CREATE Fertility, London St Paul's

CREATE Fertility is the UK's best-known proponent of "mild" or natural-cycle IVF — protocols that use lower doses of stimulation medication than conventional IVF. The St Paul's clinic is the group's central London site and is HFEA-licensed to offer both NHS-funded and private cycles.

The HFEA live birth rate per embryo transferred is 28% overall, with 33% for women under 35 and 15% for women aged 38–39. The headline rate reflects a different patient mix and protocol philosophy from conventional-stimulation clinics; readers comparing numbers across clinics should keep this in mind.

CREATE offers IVF, ICSI, IUI, egg freezing, donor eggs, donor sperm, and genetic testing. The clinic's defining commercial offer is the mild-stimulation protocol, which typically uses less injectable medication — lowering medication costs and the physical burden of a cycle, at the trade-off of fewer eggs retrieved per round.

For patients who have found high-stimulation cycles difficult to tolerate, or who prefer a lower-medication approach, CREATE is one of the few UK networks built around this philosophy. For patients whose priority is maximising egg yield per cycle, a conventional-stimulation clinic may be a better fit.